Synaptogenix Inc (SNPX)

[InTheTrenches]

- Seizures hasn't been reported as a side-effect of Bryostatin in 1500 cancer patients who were given Bryostatin, including in those who have taken Bryostatin for > 2 years, and those who have taken higher doses of Bryostatin than those in the Phase 2b Alzheimer's trial.

- Seizures hasn't been reported as a side-effect in the 100 patients who received Bryostatin for 12 weeks in the Phase 2b for Alzheimer's.

- The only incidence of seizure that I'm aware of while taking Bryostatin is Jenni Spencer, one of the 3 compassionate-use patients.

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So, let's take a closer look at Jenni Spencer's family history:

- Jenni Spencer had the PSEN1 genetic mutation for early-onset Alzheimer's.

- Jenni Spencer's mother also had the PSEN1 genetic mutation, was known to have been having seizures by age 35, and evidence of cognitive impairment was present several years before that.

- Looking at an NIH article on early-onset Alzheimer's, those with the PSEN1 mutation often have associated seizures.

https://www.ncbi.nlm.nih.gov/books/NBK1236/

AD3 (PSEN1 mutations). Age of onset is usually in the 40s or early 50s. Onset in the 30s and early 60s has been reported. Onset after age 65 years is thought to be rare. Relatively rapid progression over six to seven years is common and the disease is often associated with seizures, myoclonus, and language deficits [Fox et al 1997, Gustafson et al 1998, Menéndez 2004]. Several families have had associated spastic paraplegia with "cotton wool" amyloid plaques [Crook et al 1998, Brooks et al 2003, Ataka et al 2004, Hattori et al 2004, Raman et al 2007].

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I think any reasonable person would conclude that the seizures in Jenni Spencer were most likely caused by the course her disease progression, NOT from taking Bryostatin.