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Tuesday, April 04, 2017 2:58:27 AM
In 2016, 93% of all prescriptions for oral opioid analgesics in the United States were for IR products.
Given the greater exposure of IR products in the community, it is not surprising that population-adjusted rates of intentional abuse are 4.6 times greater and rates of drug diversion are 6.1 times greater for IR products than ER products.
For IR oxycodone, specifically, the population-adjusted rates of intentional abuse are 2.9 times higher than that of ER oxycodone and 6.8 times higher than that of ER morphine.
Conclusion
Despite the fact that the population-adjusted rate of abuse of IR products is over 4 times greater
than ER products, there are currently no abuse-deterrent IR opioid products approved in the US.
IR oxycodone, specifically, is a common target of abuse with relatively high rates of intranasal
and IV routes of abuse compared to other opioid products.
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