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Re: runncoach post# 2669

Friday, 03/31/2017 1:46:27 AM

Friday, March 31, 2017 1:46:27 AM

Post# of 21531
Why? To see the full spectrum of side effects and adverse events that may develop over time. 3 months is too short to assess that fully. I'm most concerned about seizures. I suspect bryostatin will increase an Alzheimers patients chances of developing seizures. Remember, Jenni Spencer developed seizures after going on bryostatin. A seizure is what eventually lead to her developing pneumonia and dying. I don't know how soon the severe seizures developed after she went on bryostatin. Within a 3 month window, or after?

I also want to see if any improvement is short lived (<6 mos). The approved drugs keep patients above baseline for <6 mos typically and then nosedive. Donepezil can be of benefit out to a year, best case. You can't tell if the drug is disease modifying in just 3 months, so don't assume when the 3 month results are good that they're gonna stay at that level permanently or improve further.
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