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Thursday, March 30, 2017 8:50:02 AM
"In 2008, another team of scientists studied the autopsied brains of Alzheimer’s patients who had been in a study of an experimental Elan drug, an antibody that removed amyloid plaques. They found that a number of the brains had completely cleared amyloid; the antibody worked. But those patients had shown no cognitive improvement.
At minimum, that suggested that by the time amyloid plaques appeared, a brain was too far gone to be rescued with an anti-amyloid drug. But it also raised the possibility that the plaques are markers of cell death, not causes of it, since many people have plaques but not loss of synapses or Alzheimer’s. If so, then destroying amyloid plaques — as many drugs in company pipelines still aim to do and as virtually all the failed drugs did — would not treat the disease. The same might be true of tau tangles, the deadly filaments that form inside neurons and the target of the compound that had disappointing results this week."
https://www.statnews.com/2016/07/28/alzheimers-drug-failure/
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