Wednesday, March 22, 2017 9:21:08 AM
Accesswire March 21, 2017
DEERFIELD BEACH, FL / ACCESSWIRE / March 21, 2017 / The Pharma sector is currently going through a highly charged period, especially in the regulatory realm. However, despite the uncertainty, the sector is poised to perform well in the coming period. The pharma companies engaged in niche markets are expected to push their R&D efforts further. Actinium Pharmaceuticals Inc. (NYSE MKT: ATNM) is one such firm, focusing on developing novel treatments for different types of cancers.
The latest feather in Actinium's hat is receiving positive scientific advice from the European Medicines Agency for Iomab-B drug candidate. The guidance provides clear regulatory pathway for EU approval for Iomab-B. According to the communication from the EMA, the company may use its US Pivotal Phase 3 SIERRA trial for the purpose of submitting a Marketing Authorization Application in Europe, underscoring Actinium's potential for further development.
The company is currently focusing on boosting its portfolio of patents. It recently announced receiving a notice of allowance from the United States Patent and Trademark Office for a patent claiming the methods for generating a radioimmunoconjugate comprised of actinium-225. The claims are related to a method for producing actinium-225 radioconjugates, which is a key ingredient of the company's main drug candidates, Actimab-A and Actimab-M. The radioconjugates are also used by the company for its alpha particle immunotherapy technology platform.
With this new patent, the company's patent portfolio now consists of over 60 patents. The company's growing intellectual property pipeline is expected to offer a boost to its market valuation as well. The stock has reacted positively to the recent initiatives taken by the firm. This year so far, the stock price has skyrocketed by over 57 percent, wiping out a large portion of its previous year declines.
Among other developments which had positive impact on the company's stock price is its positive growth trajectory for its drug candidates. The company is currently working on three main drug candidates, which are Actimab-A, Actimab-M, and Iomab-B. Out of these drugs, lomab-B is currently in pivotal Phase 3 trial, while Actimab-A is in Phase 2 trial. The company is currently carrying out Phase 1 trial for Actimab-M for treating patients with multiple myeloma who are unresponsive to currently available therapies.
The company is able to generate synergies, as Actimab-A, Actimab-M, and Iomab-B are interrelated and are able to draw from common pool of research. Actimab-M comprises anti-CD33 monoclonal antibody HuM-195 coupled to actinium 225 and shares its construct with Actimab-A, which is designed for treating acute myeloid leukemia. The ailment is estimated to have 20,000 new diagnoses every year. Any positive development in this regard is likely to fuel increase in the company's valuation on account of a variety of reasons. It will help diversifying the potential revenue streams for the company.
On the other hand, it may also make the company an attractive acquisition target as AML treatment offers a lucrative potential market. Recently Celator Pharmaceuticals Inc. was acquired by Jazz Pharmaceuticals for $1.5 billion. The main driver behind Celator’s valuation was its positive clinical trials showing improved survival rate for AML patients. Although Celator and Actinium Pharmaceuticals are following different trajectories, however, Celator valuations show the potential for Actinium Pharmaceuticals.
Actinium Pharmaceuticals also draws its strength from its focused approach. The company is currently involved in developing cancer treatments using its alpha particle immunotherapy platform and other technologies. The cancer treatment market was estimated to be over $83 billion in 2016 and Actinium Pharmaceuticals is looking to make its foothold in this lucrative segment through its focused approach. However, it also aims to develop novel approach for treating cancers, which will be able to overcome some of the many drawbacks of traditional treatments for cancer. This poses both challenges and opportunities for the firm.
The company is not only focusing on expanding the scope of its current drug candidates but is also researching other types of cancers where appropriate opportunities may exist. It is specifically working on preclinical development for metastatic prostate cancer, antiangiogenesis and metastatic colorectal cancer.
Additionally, Actinium Pharmaceuticals is also focusing on its APIT platform which may be customized for developing treatments for various other types of cancer. Since this platform is used for implementing state of the art mAbs based cancer treatment, expansion in its utility may open up new markets for the company, leading to more diversified revenue streams.
Actinium Pharmaceuticals' main drug candidate, Iomab-B, is currently in a pivotal Phase 3 multicenter clinical trial. The company is collaborating with the FDA for Phase 3 clinical trial design, which has recommended a single pivotal study, contingent upon trial results. Actimab-A is in the Phase 2 portion of a multicenter Phase 1/2 clinical trial in AML, while Actimab-M is being studied in a Phase 2 clinical trial.
The latest developments provided positive fillip to the stock price, which, despite its spectacular performance this year so far, is trading nearly 40 percent below its 52 weeks high price of $2.36. Keeping in mind the company's current performance and its future plans, the current price point offers the right opportunity for investors to initiate a position in the sock. While Actinium Pharmaceuticals seems poised to provide good growth in medium to long term, the current momentum wave may prove to be suitable for short-term investors as well.
Disclaimer:
Except for the historical information presented herein, matters discussed in this release contain forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to differ materially from any future results, performance, or achievements expressed or implied by such statements. WFM, Inc. is not registered with any financial or securities regulatory authority, and does not provide nor claims to provide investment advice or recommendations to readers of this release. For making specific investment decisions, readers should seek their own advice. For full disclosure, please visit: http://wwfinancial.com/legal-disclaimer/.
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SOURCE: WFM, Inc.
Recent ATNM News
- Actinium Pharmaceuticals Announces Publication of Results from the Phase 3 SIERRA Trial of Iomab-B in the Journal of Clinical Oncology • PR Newswire (US) • 09/20/2024 12:00:00 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/05/2024 09:15:52 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/05/2024 11:30:34 AM
- Actinium Provides Regulatory Update on Planned BLA Filing and Future Plans for Iomab-B in the U.S. • PR Newswire (US) • 08/05/2024 11:00:00 AM
- Actinium Expands Patent Coverage Over Iomab-ACT, its Next-Generation Targeted Radiotherapy Conditioning Agent, for Gene Edited Stem Cell-Based Therapies for Non-Malignant Indications • PR Newswire (US) • 08/01/2024 12:00:00 PM
- Actinium Announces FDA Clearance of Iomab-ACT Targeted Conditioning IND Application for Sickle Cell Disease Patients Undergoing Bone Marrow Transplant in Collaboration with Columbia University • PR Newswire (US) • 07/25/2024 12:45:00 PM
- Actinium Pharmaceuticals to Present at the 3rd Annual Targeted Radiopharmaceuticals Summit US • PR Newswire (US) • 07/25/2024 11:30:00 AM
- Actinium Presents First Ever Data Demonstrating Actimab-A in Combination with Leading Menin Inhibitors Leads to Anti-Tumor Control and Potent Leukemic Cell Killing in Preclinical Acute Myeloid Leukemia Models at the 2024 EHA Congress • PR Newswire (US) • 06/17/2024 12:00:00 PM
- Actinium Highlights Oral Presentation at EHA 2024 Annual Congress Featuring Improved Outcomes in TP53 Positive Patients Receiving Iomab-B in the Phase 3 SIERRA Trial • PR Newswire (US) • 06/14/2024 12:30:00 PM
- Actinium Announces Results of Actimab-A + CLAG-M Combination Trial Highlighted in Oral Presentation at the 2024 Society of Nuclear Medicine & Molecular Imaging Annual Meeting • PR Newswire (US) • 06/11/2024 12:30:00 PM
- Actinium Highlights Mutation Data from the Phase 3 SIERRA Trial of Iomab-B and Novel Linker Technology to Support Solid Tumor Antibody Radiation Conjugate Development at the 2024 Society of Nuclear Medicine & Molecular Imaging Annual Meeting • PR Newswire (US) • 06/10/2024 12:30:00 PM
- Actinium to Host KOL Webinar to Discuss Iomab-ACT Commercial CAR T-Cell Therapy Trial Design, Objectives and Potential Market Opportunity • PR Newswire (US) • 05/15/2024 12:30:00 PM
- Actinium Announces Oral Presentation Detailing Improved Survival Outcomes in TP53 Positive Patients at the EHA 2024 Annual Congress and Presentation of Long-Term Efficacy Results in Older Patients Receiving an Iomab-B Led Bone Marrow Transplant in the Phas • PR Newswire (US) • 05/14/2024 10:38:00 PM
- Actinium Announces Multiple Abstracts Highlighting its Antibody Radiation Conjugates Iomab-B and Actimab-A and Novel Linker Technology for Solid Tumors Accepted for Presentation at the 2024 Society of Nuclear Medicine & Molecular Imaging Annual Meeting • PR Newswire (US) • 05/13/2024 12:30:00 PM
- Actinium Announces KOL Webinar to Highlight Recently Announced Iomab-ACT Trial with Leading FDA Approved Commercial CAR T-Cell Therapy Being Led by the University of Texas Southwestern • PR Newswire (US) • 05/07/2024 12:00:00 PM
- Actinium Highlights Ability of Iomab-B to Overcome High-Risk TP53 Mutation Resulting in Significant Improvement in Overall Survival in Patients with Active Relapsed Refractory AML at the European Bone Marrow Transplant Annual Meeting • PR Newswire (US) • 04/18/2024 12:00:00 PM
- Actinium Announces Iomab-B Phase 3 SIERRA Trial Results Demonstrating Survival Benefit in High-Risk Relapsed or Refractory Acute Myeloid Leukemia Patients with TP53 Mutations Accepted for Oral Presentation at the 50th European Bone Marrow Transplant Annual • PR Newswire (US) • 04/01/2024 12:00:00 PM
- Actinium Announces Clinical Trial to Study Iomab-ACT Targeted Radiotherapy Conditioning with Leading FDA Approved Commercial CAR T-Cell Therapy • PR Newswire (US) • 03/26/2024 11:18:00 AM
- Actinium Pharmaceuticals Launches Actinium-225 Focused Strategic Initiative to Leverage Proprietary Cyclotron Based Manufacturing Technology to Address Growing Market Demand • PR Newswire (US) • 03/11/2024 11:30:00 AM
- Actinium Announces Iomab-B Markedly Increases Long Term Survival in Patients 65 Years or Older with Active Relapsed or Refractory AML in the Phase 3 SIERRA Trial at the 2024 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT® and CIBMT • PR Newswire (US) • 02/26/2024 12:30:00 PM
- Actinium Highlights Improved Survival with Iomab-B in TP53 Positive Relapsed Refractory Acute Myeloid Leukemia Patients in the SIERRA Trial and Other Presentations at the 2024 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT® and CIB • PR Newswire (US) • 02/23/2024 12:30:00 PM
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- Actinium Announces Acceptance of Five Abstracts for Presentation at the 2024 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT® and CIBMTR® • PR Newswire (US) • 01/02/2024 12:30:00 PM
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