BioCryst Pharmaceuticals,Inc. (BCRX)

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BioCryst Reports Positive Interim Results from its APeX-1 Trial
By GlobeNewswire, February 27, 2017, 06:00:00 AM EDT
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Reduction of 63% in overall attack rate in HAE patients with severe disease (p=0.006)

RESEARCH TRIANGLE PARK, N.C., Feb. 27, 2017 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) today announced results from an interim analysis of its Phase 2 APeX-1 trial in hereditary angioedema (HAE). APeX-1 is a dose ranging trial designed to evaluate the efficacy, safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered once daily (QD) BCX7353 for 28 days, as a preventative treatment to reduce the frequency of attacks in HAE patients.

"The results of this interim analysis are extraordinarily encouraging," said Dr. Emel Aygören-Pürsün, MD, principal investigator for the APeX-1 trial and Head of Interdisciplinary Competence Center for Hereditary Angioedema, and Specialist in Internal Medicine and Hemostaseology Department of Child and Adolescent Medicine, Goethe University Hospital Frankfurt. "Confirmation of the results would lead to a huge step forward in the treatment of hereditary angioedema, towards an effective, safe and easy to administer prophylaxis for the debilitating attacks connected with this condition."

"We are extremely excited to have such a strong treatment effect in reducing HAE attacks with our once daily oral therapy," said Jon Stonehouse, Chief Executive Officer & President of BioCryst. "What is even more encouraging is the dramatic benefit seen in the reduction of peripheral attacks and mixed peripheral and abdominal attacks. A once daily oral therapy with an 88% reduction in these attacks has the potential to make a huge difference in HAE patients' lives."



Read more: http://www.nasdaq.com/press-release/biocryst-reports-positive-interim-results-from-its-apex1-trial-20170227-00320#ixzz4ZtU9l3Of