Patients are so much better informed nowadays -- about different treatment options and their effectiveness / symptoms -- it would be difficult to create two identical arms.
The fact that patients are turning down free avastin tells me that they're not satisfied with its effectiveness (or lack thereof) and are searching for other options.
The avastin only arm still needs enough patients to have statistically significant results, but the results will confirm what many other trials and hundreds of patients have shown: avastin is ineffective in extending OS.
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