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Re: F1ash post# 994

Sunday, 02/19/2017 5:44:46 PM

Sunday, February 19, 2017 5:44:46 PM

Post# of 21531
Anavex HAS qualified why the 5 patients dropped out. Do your DD. One fell off their radar entirely and disappeared. Others had delerium and other symptoms which may or may not have been related to the drug. 5 dropouts, that's not that many dropouts for a trial of 32.

For the 38 failed hiv and cancer trials which included looking at safety of bryostatin, how long were those trials? Every clinical trial bryostatin has entered, has failed. Keep in mind, Ph 2 is supposed to show safety in ALZHEIMERS, not cancer! Ph 1 is to show safety in people that don't have Alzheimers. One IV treatment or 7 over 3 months, as in the Ph 2b trial, does not prove the drug is safe in Alzheimers patients.

Synaptogenesis can cause seizures in Alzheimers patients involving suffering and sometimes death. It can also cause serious psyche/behavioral problems for people with Alzheimers. Also, elevated growth factors over time is also a concern. I expect high incidence of side effects w/long term use of this drug for elderly people with Alzheimers.

The drug does not get at the underlying cause of Alzheimers: protein misfolding, oxidative stress, calcium imbalance, mitochondria-endoplasmic reticulum dysfunction.
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