Synaptogenix Inc (SNPX)

[SF Wolf]

NTRP: 2/13/17 BIO CEO & Investor Conference
My notes

Dr. Wilke:
Minute 4:14: we are unique in that we are stating that we can regenerate synapses and synaptic networks. And by regenerating these synapses and synaptic networks we can actually reverse Alzheimer’s disease even in advanced patients.

Minute 4:29: we believe we have a uniquely regenerative mechanism that actually will show strong clinical benefit in our clinical trial which is different than just treating or preventing the formation of amyloid plaque.

Minute 5:18: we are pretty excited about our upcoming Phase 2 top line data in April 2017, as I said in moderate to severe AD patients, which we believe will be a pivotal inflection point for the company.

Dr. Alkon:
Minute 17:54: I do want to say that Bryostatin is one of a platform of drugs that we have. It is our lead compound now because it has experience in the patient population and we know it’s well tolerated. But we have 40 or so other compounds some of which are even more potent and even more specific and have proprietary composition of matter protection which we can use for second and third generation of drugs.

Minute 23: (Bryostatin) is well positioned to virtually…take care of every major aspect of this disease. So it is multi modal, multi modal means that we can look at prevention, slowing down progression, and actual reversal of Alzheimer’s disease. Which is what is in our current Phase 2 trial.

Minute 25:45 (refer to Slide 40 – Bryostaten Compassionate Use Program: Severe Alzheimer’s Disease “No other reports have ever shown comparable benefits in such severely demented patients”) These are our compassionate use patients…we saw major reversal of disease that’s why we teed-up our Phase 2 trial in the way we did for severe (Alzheimer’s) patients to see reversal. To see not just a reduction in the rate of decline…but a flipping, a changing of the sign of what happens, for example, with the preferred metric of advanced Alzheimer’s disease, the Severe Impairment Battery.
https://www.veracast.com/webcasts/bio/ceoinvestor2017/18111483071.cfm