Biotech Values

[biomaven0]

I'd add that low-cholesterol diets have been similarly ineffective at reducing mortality and bile sequestrants are another class of cholesterol-lowering drugs that don't actually do anything good.

I'd add that niacin clearly reduces LDL levels - from 74 to 65 in the big NEJM study that showed excess mortality.

So basically I believe that lower cholesterol is indeed good, but you have to be careful how you achieve it because homeostatic feedback loops kick in that tend to reverse any benefit.

I also believe that excess homocysteine over long periods is a problem - less of an issue now in the US that folic acid supplementation has been introduced and many people take vitamin supplements that include B6 and B12 anyhow.

Peter