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Re: sox040713 post# 170438

Tuesday, 01/31/2017 4:04:58 PM

Tuesday, January 31, 2017 4:04:58 PM

Post# of 402966
The biologics achieve PASI75 scores of 60-70% and cost around $50k/yr with some harmful side effects.

Otezla's PASI75 score was 33%, again with unpleasant side effects.

If Purisol simply duplicates in 2a results with few side effects we'll have a multi-billion dollar a year winner here. Of course with the higher dosage we expect even better results....maybe 60-70% like biologics....talk about blowing the doors off.....

"PDE4 Inhibitors. Celgene’s twice daily oral therapy for psoriasis, Otezla (apremilast), is a small molecule inhibitor of the enzyme phosphodiesterase 4. In the pivotal trial for apremilast, 33.1% of subjects receiving drug achieved PASI75, compared to 5.3% for patients on placebo. Apremilast is generally well tolerated, although some patients experience gastrointestinal side effects, including diarrhea, nausea, and vomiting. Treatment is estimated to cost approximately $22,500 per year."
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