Cytodyn Inc (CYDY)

[pearsby09]

In the present study, the duration of antiviral activity increased somewhat as the i.v. dose was increased from 5 mg/kg to 10 mg/kg. However, neither i.v. dose would appear to support highly infrequent (e.g., monthly) administration, and Emax analysis indicated that further increases in i.v. dose would result in incremental increases in antiviral effects. In a study of s.c. PRO 140, significant antiviral effects were observed when the drug was administered weekly or every other week, and virologic suppression was maintained between successive doses (7). While both i.v. and s.c. dosage forms have demonstrated favorable antiviral and tolerability profiles, s.c. PRO 140 was selected for further development on the basis of its potential to be self-administered by patients. Self-administration may offer greater convenience for many patients. Nevertheless, the s.c. dosage form is undergoing clinical study, and i.v. administration may be preferred in certain treatment settings.