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Re: jboatswain post# 9130

Tuesday, 01/10/2017 11:08:00 PM

Tuesday, January 10, 2017 11:08:00 PM

Post# of 233621
Another good post jboatswain. The link however discusses the differences between NON competitive versus allosteric inhibition, which is not the same as competitive inhibition as in the pro 140 monAb model. Do we see resistance and rreceptor hyperplasia in allosteric models thus far ? A competitive binding away from active site might inactivate the ccr5 receptor, yet turn on the genetic messaging that says "we need more receptor!"
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