Cytodyn Inc (CYDY)

[jboatswain]

Pro 140 and Maraviroc has same MOA. I asked a question about the difference between Maraviroc and Pro 140. The only sensible answer I got on this forum is that Pro 140 has less adverse effects compared to Maraviroc. Maybe, Pro 140 is more effective than Maraviroc too. Pro 140 and Maraviroc belong to one class of drugs. The mechanism of action varies between classes: for more, check the picture I uploaded at the bottom of this post.



From http://www.columbia.edu/itc/hs/medical/pathophys/id/2009/hivantiColor.pdf
FDA-approved Antiretroviral Classes


• Nucleoside reverse transcriptase inhibitors (NsRTIs)
• Nucleotide reverse transcriptase inhibitor (NtRTI)
• Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
• Protease Inhibitors (PIs)
• Fusion inhibitor
• CCR5 antagonist
• Integrase inhibitor




If you see the above pic, one can see why Pro 140 can replace HAART drugs to a large extent. Whether Pro 140 can completely replace HAART regimen in R5 strain patients--is a question for the investigation. That's what 300 patients P3 trial is for. Earlier, longs on this board discounted any criticism about Pro 140 resistance by saying it is all due to screening issues (this is the NONSENSE peddled on this board for very long). However, Pourhassen has given us an answer: CCR5 density and resistance are related. This is for the phase 3 to figure out: can increasing the dosage fix the resistance issues or not? To what extent, increasing the dosage can prevent resistance? Even if the dosage is increased to maximum, even if Pro 140 is injected twice a week, can we see resistance to Pro 140 drug. These are questions for P3. Will wait and see.