Cytodyn Inc (CYDY)

[MJbiotech]

HAART drugs and Pro140 have completely different MoAs
Long time lurker here as I'm heavily invested (long) in CYDY, but I have to refute your statement, pearsby90. You could not be more incorrect when you say that HAART and Pro140 have the same MoA.

There are ~24 approved drugs that fall into the HAART category, and of those 9 are protease inhibitors, 12 are reverse transcriptase inhibitors, and 3 are integrase inhibitors. All of these HAART drugs inhibit viral replication. They all work inside of the cell to inhibit specific enzymes that HIV uses to make more copies of itself. Hence, they are orally dosed small-molecule drugs.

Pro140 act by a different and completely unrelated MoA as it is an entry inhibitor. It works on the surface of the cell to prevent HIV from infecting new cells. It has no effect on viral replication, and all of the HAART drugs listed above have no effect on the virus's entry into new cells.

Completely different MoAs.

It is interesting to note that there is one small molecule, orally dosed drug that is a CCR5 entry inhibitor. Maraviroc was approved back in the late 2000s and has never gained traction in the industry, despite OK efficay in clinical trials.