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genisi

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genisi

Re: jq1234 post# 207385

Wednesday, 12/28/2016 4:08:11 PM

Wednesday, December 28, 2016 4:08:11 PM

Post# of 251666

We'll see if SGEN clinical hold is target related or payload related or combination of the two

SGEN showed in preclinical study that PBD based ADCs can cause substantial bystander killing effects probably due to their potency or perhaps better ability to diffuse across cell membranes than other payloads.

http://cancerres.aacrjournals.org/content/canres/early/2016/04/20/0008-5472.CAN-15-1795.full.pdf
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