I can give the translation from google translate, but I'm hoping to get the original presentation posted here by pistolpete. Then you can follow along.
Of course I don't know how she explained things other than what was in the PowerPoint presentation.
Is diabetes curable in the future?
Diabetes type 1 therapy by transplantation
encapsulated insulin-producing cells
Dr. Eva Maria (Lilli) Brandtner
VIVIT Vorarlberg
BioLAGO science meets industry
Constance, 15th December 2016
What is type 1 diabetes?
healthy type 1 diabetes
Immune cells
destroy insulin
producing
Beta cells
Can pancreas
No insulin
produce
more glucose in your blood goes to insulin
the cells
Pancreas
produces
Insulin
Glucose
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High blood pressure, sexual disorders, etc.
SYMPTOMS
• Frequent urination
• Strong thirst
• Weight loss
• Malaise, fatigue, and weakness
• Blurred vision
• Loss of consciousness
unknown
< 2 2-5 5-10 10-25 > 25
Around the world (by 2015):
415 million adults
500 000 children
5-10% OF T1D
3% global increase of T1D Neuerkrankugen per year
International Diabetes Federation
T1D new disease per 100,000 children per year
International Diabetes Federation
Who has diabetes?
Is diabetes curable?
Betazell transplantation
• Treatment by injection of insulin / insulin pumps
• Advanced cases of type 2 diabetes
• Healing: pancreatic and Betazell transplantation
• today: only about 1000 patients worldwide transplanted
• Shortage of donor organs:
1 transplant/625 T1DM patients. 2-4 Pankreata/patient
• Serious risks and side effects of immune supprimierenden
Medications for graft rejection
What can cell encapsulation?
Sugar
Insulin
Immune
Cells
• allows the transplant of alien cells without immune supprimierende
Medicines
• Diameter: 0.7 mm
• contains up to 10,000 cells
Cellulose sulphate capsules
• electron microscopic images
• on cotton basis
• can be frozen (including cells)
confidential data
Does it work?
Blood sugar levels of animals under the following conditions:
(?) diabetic control group (n = 5).
(?) animals with graft, Explantation of capsules on day 15 (n = 5)
(?) Explantation of capsules at day 45 (n = 5)
(?) Explantation of capsules at day 150 (n = 5)
Time (days)
Blood glucose (mg/dl)
Try encapsulated pig beta cells in diabetic rats
All transplanted animals had normal blood sugar levels during the entire
Test duration (150 days) or until the grafts were removed.
What kind of cells?
MELL-CELLS UTS Australia
• Liver cells: robust
• genetically modified so that they make insulin,
Save and increased blood sugar levels
unlock
pmol insulin/10 6 cells
Glucose (mmol/l)
Insulin secretion
(relative to the level before the stimulation)
Group number
Start the stimulation
(20 mM glucose)
At the end of the
Stimulation
Prof. Dr. Walter Günzburg
Dr Brian Salmons
Dr. John Dangerfield
Dr. Kenneth L. Waggoner
Dr. Gerald W. Crabtree
Dr. Eva Maria Brandtner
Prof. Dr. Matt Löhr
Prof. Axel
Kornerup Hansen
Prof. Dr. Ann Simpson
Dr. Brenton Hadi
Dr. Constantine Konstantoulas
Prof. Dr. Thomas Stratmann
Prof. Dr. Rüdiger Wanke
Prof. Dr. Eckhard Wolf
Dr. Andreas Blutke
This research was supported by a
Marie Curie FP7 integration Grant as part of the 7th European framework programme
AI
