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genisi

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genisi

Re: masterlongevity post# 206877

Sunday, 12/11/2016 2:53:35 PM

Sunday, December 11, 2016 2:53:35 PM

Post# of 251661

hardly any AD scientist believes in the sink hypothesis

Well, someone at LLY must have at the time smile

But seriously, I can see why the hypothesis was appealing - all it takes is to reduce a-beta levels in the periphery with an antibody or a BACE1 inhibitor, no need to penetrate the BBB to hit the target - decreasing deposited a-beta in the brain.
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