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Re: dewophile post# 206562

Friday, 12/02/2016 5:47:39 PM

Friday, December 02, 2016 5:47:39 PM

Post# of 253269

you only need a fraction of CD47 receptors engaged to get phagocytosis. They mention receptor occupancy in the abstract and I think this will be described in more detail sat and/or monday



So how would you reconcile that with the Ladenburg call where the CEO said of the 1b they "wanted to make sure that we flood the solid tumor with as much TTI-621 as we can and get as much of a blockage as we can", and were therefore going IT injection? He mentioned twice that this choice was based partly on their preclinical data.
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