Momenta Pharmaceuticals, Inc. (MNTA)

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New pre grant patent application,

http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=2&f=G&l=50&co1=AND&d=PG01&s1=momenta&OS=momenta&RS=momenta

METHODS OF MANUFACTURING POLYSACCHARIDE COMPOSITIONS

"[0085] In one aspect, described herein are methods of manufacturing a LMWH (e.g., M402) pharmaceutical composition, the method comprising: determining for a sample of the batch whether the activity of the LMWH preparation is within a predetermined range by: exposing the sample to an assay, wherein the assay comprises a population of cells that respond to a stimulant (e.g., a protein, e.g., a cytokine, e.g., SDF1.alpha.) in the absence of the LMWH within a predetermined first range, in response; and determining, in the assay, whether the cellular response in the presence of the LMWH is within a predetermined second range; and formulating the batch of LMWH (e.g., for medical use), to thereby manufacture a LMWH (e.g., M402) pharmaceutical composition. “

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