OncoSec Medical Inc (ONCSQ)

[hschlauch]

Just a little more refinement...

Reducing suppressor cells in combination with an anti-pd-1 agent is synergistic to a degree. In fact, I have read and heard that anti-CTLA-4 agents harbor the same MOA, i.e. they don't actually improve the number of TIL, but they reduce the number of suppressor cells.

Therefore, I think Bavi would be akin to using an anti-CTLA-4 agent with an anti-pd-1. If true, efficacy and safety with a Bavi and anti-pd-1 or anti-pdl1 combination should look similar to an anti-pd1 and anti-CTLA-4 combination. Mixing all three together though would not only be very expensive, but would theoretically be very toxic with negligible added benefit.