Tuesday, October 18, 2016 4:33:03 PM
Acura's Aversion is no more "crap tech" than the rest of the "crap tech," which includes all ADF's in my opinion. None of them will prevent drug abuse, but they may help prevent PRESCRIPTION drug abuse. When ADF OxyContin replaced non-ADF OxyContin, the prescriptions for OxyContin went down by 30% and heroin overdose deaths increased by 30%. ADF's only help prevent abuse of drugs from the pharmacy- they actually increase abuse of drugs from the street corner. Now with illicit fentanyl causing more overdose deaths than ever, ADF's are likely to cause more deaths than they prevent.
As for physical barrier "hard shell" ADF's, everybody and their brother can make a crush-resistant tablet. Whether or not that crush-resistant tablet can sufficiently pass HAL studies in order to receive ADF label is another question, and whether or not that crush-resistant tablet is LESS SAFE than the non-ADF version is another question entirely (see Opana). Of the seven approved drugs with ADF label, four are "physical barriers" and three are "antagonists."
As for the KemPharm-Acura deal, this is what a license for a hardshell ADF is worth:
A few million dollars and "a low single-digit rate" is what this technology is worth. So for those IPCI players who are lurking, this is what your "SUPER-LUCRATIVE" (choo! choo!) partnership for Rexista would look like. What Big Pharma needs to license an unproven hardshell ADF? They just make their own hardshell with their own engineers for nothing and test it themselves. And they would probably avoid gimmicky add-ons like "stigmatizing blue dye," which is a known mitochondrial poison and will kill more people than Opana, if it makes it out of AdComm, which it won't.
Historic note: Until his life's destiny was further clarified, Robin Hood spent several years robbing from the rich and giving to the porcupines. (G. Larson 7/26/82)
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