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Re: Titan V post# 36060

Friday, 10/07/2016 12:55:15 PM

Friday, October 07, 2016 12:55:15 PM

Post# of 48316
Actually Titan there is a difference, Refractory refers more to the stubborn tumors that although they have a low TIL environment are still resistant to a treatment regimen due to other factors.

My understanding is it's the same trial. Anytime there is talk about a metastastic melanoma combination study, They can be referred to as a phase 2 or phase 2B clinical trial. Phase IIA is specifically designed to assess dosing requirements (how much drug should be given). Phase IIB is specifically designed to study efficacy (how well the drug works at the prescribed dose. I do think that they have been working with both aspects during this phase 2 trail.