Intellipharmaceutics International Inc. (IPCI)

[WeeZuhl]

100% Complete Confidence

Again 100% complete nonsense and blatantly false that Rexista could cause users to turn blue and die hahahhaahah

Which of the 2 blue dyes will be concentrated in Rexista? The suspected carcinogen or the proven carcinogen? The FDA Advisory on enteral exposure of blue dyes says that both are equally likely to cause severe sepsis and possible death when systemically absorbed from the G.I. tract during sepsis.

What concentration of blue dye will be used in Rexista? What effect does opioid-induced constipation have on the transit time and G.I. clearance of blue dye? The FDA Advisory specifically identifies at-risk subgroups, including inflammatory bowel disease, sprue, trauma, surgery, and kidney disease. Have there been any studies to prove that Rexista's concentrated blue dye is not being systemically-absorbed in these subgroups?

Do you have 100% complete confidence that this amount of blue dye is safe for EVERY user FOREVER? Because I have 100% complete confidence that the blue dye provides zero benefit to the legitimate user. Not only is Rexista a ticking time bomb, but it is also an ethical nightmare.

IPCI's Rexista OxyContin NDA isn't 2 quarters behind schedule hahahahahahaha

You must be using Canadian math. First they said Q2 then Q2/3 then July then Aug now Q4. Go find your own links, they're all there. Q4-Q2 is 2 quarters behind. Facts.



http://www.nejm.org/doi/full/10.1056/nejm200010053431416#t=article

Although both patients had serious underlying illnesses, their condition was improving before they received the dye and turned color. We hypothesize that the refractory hypotension and metabolic acidosis seen in these patients may be explained by the known biochemical effects of this dye, since neither patient had hypotension or severe acidosis immediately before the discoloration. The hyperthermia in the child may represent an uncoupling effect of FD&C blue dye no. 1 that is not apparent in vitro. We encourage judicious use of this food dye in patients with sepsis or other illnesses associated with increased gastrointestinal permeability.

James P. Maloney, M.D.
Medical College of Wisconsin, Milwaukee, WI 53226

Ann C. Halbower, M.D.
Brian F. Fouty, M.D.
Karen A. Fagan, M.D.
Vivek Balasubramaniam, M.D.
Adrian W. Pike, Ph.D.
Paul V. Fennessey, Ph.D.
Emory University, Atlanta, GA 30322

Marc Moss, M.D.
University of Colorado, Denver, CO 80262