how about clvs ? No adcom for ruca is a big deal.did clvs show up on your screen ?
I believe it will be a lot more useful if you go back using hindsight ie after a real and meaningful event occured after the unusual signal(s) to validate these indicators.
a tradeable indicator imo would have a "good" S/N ratio. Beside if unusual activities in price and vol is a good indicator for biotechs, logic tells me it should good for all.
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