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Home The Journal Current Issue Original research Volume 362, Number 9380 26 July 2003 Research letters Treatment of SARS with human interferons J Cinatl, B Morgenstern, G Bauer, P Chandra, H Rabenau, H W Doerr Effective antiviral agents are needed to treat severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection. We assessed the antiviral potential of recombinant interferons against two clinical isolates of SARS-CoV--FFM-1, from Frankfurt patients, and Hong Kong--replicated in Vero and Caco2 cells. Interferon ß was five to ten times more effective in Caco2 cells. Interferon effectively inhibited SARS-CoV replication, but with a selectivity index 50-90 times lower than that for interferon ß. Interferon was slightly better than interferon in Vero cell cultures, but was completely ineffective in Caco2 cell cultures. Interferon ß could be useful alone or in combination with other antiviral drugs for the treatment of SARS.
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