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Re: Regis999 post# 3763

Monday, 08/15/2016 8:17:02 PM

Monday, August 15, 2016 8:17:02 PM

Post# of 10346
Hi Regis - any comments on this post from SA

"Preclinical Mice vs Human trial results

ARTH had published at least 4 pre-clinical studies from Feb'15 to Apr'15

In all cases - AC5 showed TTH of less than 30 secs - which is significantly low.

Do we know what was actual TTH in these patients?

Here are comparisons from preclinical trial PRs

Gelatin - 4 times more time

Cellulose based Fibrin sealant - 4 times more time

Fibrin sealant - 50% more time

Gelatin thrombin hemostat - 200% (2 times) more time

Compared to these numbers - 41% less time looks not as attractive as animal studies - although it is very good.

Do we know which agent was used as comparator and what was absolute TTH?"