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Monday, August 15, 2016 8:17:02 PM
"Preclinical Mice vs Human trial results
ARTH had published at least 4 pre-clinical studies from Feb'15 to Apr'15
In all cases - AC5 showed TTH of less than 30 secs - which is significantly low.
Do we know what was actual TTH in these patients?
Here are comparisons from preclinical trial PRs
Gelatin - 4 times more time
Cellulose based Fibrin sealant - 4 times more time
Fibrin sealant - 50% more time
Gelatin thrombin hemostat - 200% (2 times) more time
Compared to these numbers - 41% less time looks not as attractive as animal studies - although it is very good.
Do we know which agent was used as comparator and what was absolute TTH?"
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