Avid Bioservices Inc (CDMO)

[Protector]

biopharm, goo article. We know the answer to the research question: How can we block PS :)

I figure that these researchers by know must have found out that the PS receptor that expresses on phagocytes is TIM-4. They will like to hear that in the Hokaido University in Japan because they are the anti-TIM-4 team.

Who at PPHM that reads my posts went to Japan? Maybe someone needs to tell them that there are MANY PS receptors and that JUST binding TIM-4 will not help because the army of phagocytes will keep growing because if PS exposing cells (no matter whether it is due to Apoptosis or to viral/cancer related damage) are NOT engulfed by phagocytes (because they where disabled by, say, TIM-4 so that PS cannot bind them and tell them 'EAT MORE') then the still 'free' PS keeps crying out louder and louder : APOPTOSIS, pls send more garbage trucks (phagocytes) and hence more targets vehicles for the Dengue or West Nile viruses viruses.

To solve the problem you need to bind ALL PS receptors which says : This PS is NOT part of APOPTOSIS, pls send troops first, garbage collection later.

That was indeed the sentence to highlight :)

Infection of cells by dengue or West Nile viruses is markedly enhanced when phagocytes express receptors that recognize and bind PS.

Remember this post with PS receptor variety?


Tim-4 Is Involved in Both the Adhesion and Ingestion Processes of Phagocytosis of Apoptotic Cells.