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Re: matthewverymuch post# 10068

Sunday, 07/31/2016 9:19:56 AM

Sunday, July 31, 2016 9:19:56 AM

Post# of 16911
That's a nice find, thanks for posting!

Key takeaways for me were:

1. They plan on not just filing the IND, but commencing the Phase I in 2016 for ropinirole (parkinsons).

2. Both ropinirole and T3 will involve a Phase I and then go straight to "one maybe two" (Sunil's words) Phase III's. So it's conceivable that Titan could have Parkinsons in Phase III trials by the end of 2017, with an NDA being filed (and approved if priority review is obtained) in 2019. T3 in 2020.

Just my speculation, but assuming probuphine royalties are available to fund operations, I would expect them to keep both Parkinsons and T3 "in house" through the Phase III's and not outlicense them. This will allow them to partner with a sales channel and get a much higher royalty if approved. Other development efforts (new compounds from BP) will most likely be in partnerships, where TTNP gets a smaller royalty percentage but is paid all of its development expenses.


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