Avid Bioservices Inc (CDMO)

[faxorama]

mojo, I think the 6mg dose was in response to the largest dose showing the greatest efficacy (slightly greater) and a desire to simply find greater efficacy at a higher dose. One of the objectives of 1a is to find max tolerated dose. The highest (3mg) dose showed greater efficacy but not in an exponential way over lower doses. So while 6mg could show greater efficacy it may only be somewhat higher.

In 1a trial (lowest to highest comparison)
3.0 mg dose 50% were greater than .6 log reduction (.8 average)
.1mg dose 33% were greater than .6 log

On the other hand some here hope for a "cascade effect" at the higher dosing (6mg) but a more likely effect is a better sustained response which was implied in the 1a data.

While your numbers are interesting I'm not sure what merit or use they have. All we know is the guinea pig model (with a different virus) had little efficacy on a single dose and cured 50% on multi-dosing with excellent sustained response for the survivors. I think the concensus here is a hope for 2 to 4 log reduction for the best 1b hcv cohorts.