Sunday, July 24, 2016 1:43:45 PM
Obviously.
Not sure where you got that idea, but I have been a proponent of combination therapy for a while and stated so on this board several times.
No, the conclusion is that single agent IOs works EXTREMELY well for a good percentage of the patients treated. Different of such single agents have been approved and are generating a lot of money for companies who own them, and for investors who own shares in those companies. Bavi, PPHM, and PPHM investors are not part of this group so have not shared in such monetary success.
I don't believe that IOs as single agents are the end all, and the companies involved in such work do not either. There is a race going on to combine IOs which each show efficacy as single agents in the hopes of improving efficacy and showing enough synergy so that the dosages of the single agents can be reduced to lower side-effect profiles. Bavi is not a major player since it has failed in all trials so far. Sure PPHM is pushing it and hoping something will come out of it, but they are late to the game. They also have no money behind them to push it forward in the race, so are essentially bringing a water pistol with little to no water in it to a gun fight. Because of this, the odds are decidedly against it.
The focus of you and many people on this board has been on combinations of IOs. I feel what has been underemphasized is single agents IOs in combination with targeted anti-proliferative antibodies (e.g. Herceptin) or growth factors (e.g. tamoxifen or Xtandi) or with antibodies that specifically bind cancer cell antigens and have been shown to elicit efficacy own their own. That greatly expands the realm of single agent IOs that have shown efficacy on their own.
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