Vin, my responses to your responses
Quote:1 - Yes, the stock price is bad; so are the vagaries of biotech.
Many biotech stocks make money for their investors.
Yes, and biotech is as stable as McDonalds and Phillip Morris; everybody makes money; nobody loses money.
Quote:2 - But the science has not changed from day one. Nor from the first day of SUNRISE suspension post first look-in. PS is still a highly immunosuppressive molecule. Bavi and betabodies still cover up PS to turn the immunological lights back on. Nothing has changed on that front. Nothing.
The hoped for mechanism for how Bavi might work hasn't changed, but the Sunrise failure along with ALL the previous clinical trial failures makes it far less likely Bavi will prove an effective anti-cancer agent. What has changed is that several single agent anti-ligand or anti-receptor treatments have been approved and are efficacious. Big money is behind these to expand their usage as single agents, and also in combination. That also doesn't bode well for PPHM and Bavi.
Your anti-ligand and anti-receptor treatments have a 30% response rate at best; the side effects are significant and limit treatment severely for many; not really as promising as you say.
Quote:3 - Chemo is poison. Bavi doesn't work well in a poisonous environment apparently, despite the fantastically weird super efficacious Doxi control arm. So are the vagaries of biotech.
Chemo is still widely used and can be very effective, as cisplatin in testicular cancer shows. There is no evidence or data to back up your statement that the Sunrise control arm was super efficacious. I have stated multiple times that it doesn't make sense to combine cytotoxic agents with immune modulators, but apparently the PPHM "brain" trust are too stupid to recognize the problems. That doesn't bode well for PPHM investors.
Chemo works for essentially two cancers; you are right that testicular cancer is one of them; the other is Non-Hodgkins lymphoma; as for the big ones, unfortunately the treatments are dismal; the mortality for breast cancer s/p chemo hasn't changed much in 50 years; colon, pancreatic, lung, and ovarian have similar terrible track records; try cisplatin and adriamycin and doxorubicin - see if your heart is still beating afterward (awful cardiotoxicity)
Quote:4 - BMS, Merck, Roche, and AZN have invested BILLIONS in the anti-PD1, anti-PDL1 mabs. Only BMS and Merck are raking right now because they were first in line. But the others aren't giving up. Why?
That is completely false. Roche and AZN sure as hell aren;t giving up. If those giants were giving up then PPHM is even worse off than I have stated.
OK, try reading my sentence again. I said they are NOT giving up. You misread the sentence, friend.
Quote:5 - Well, how 'bout combo therapy. It is a phenomenon well-known to the alternative/complementary medical field for decades. In fact, the whole Wall Street biotech immunotherapy racket is a rip-off of what natural holistic doctors have been saying for years.
As John McEnroe used to say, You cannot be serious!
Millions and millions of people have pursued the complementary route to address their cancers; Germany anyone? You are inside a modern box of thinking and I wish you a happy escape.
Quote:6 - You don't treat breast cancer with just DIM (diindolylmethane, an anti-estrogen supplement); you add beta-carotene from natural sources (usually 8-10 blended organic carrot juices per day, plus duneliella algae food carotene - often to the tune of 200,000 IU daily), plus massive doses of Vitamin C, plus a no-sugar diet, plus alpha-lipoic acid, plus selenium, plus extra zinc to improve the zinc/copper ratio, plus Turmeric, plus Holy Basil.....etc.
As John McEnroe used to say, You cannot be serious!
You have much reading to do. Virtually all of the above supplements/vitamins listed above will shift the immune system to the Th1 cell-mediated immunity axis (cancer-fighting); IL-2, Natural Killer, CD8, and macrophages are all potentiated strongly by many natural remedies; have you forgotten that the taxanes were first isolated from the Yew tree?
Quote:Well, Warren Buffet always says, "Buy and hold...forever."
Warren Buffett never said anything even remotely close to that.
See 4ourRetirement's Buffet video link
Regards,
Joe
