THE ESSENTIAL SCIENCE HAS NOT CHANGED
A few thoughts:
1 - Yes, the stock price is bad; so are the vagaries of biotech. The delay is painful for all. No doubt.
2 - But the science has not changed from day one. Nor from the first day of SUNRISE suspension post first look-in. PS is still a highly immunosuppressive molecule. Bavi and betabodies still cover up PS to turn the immunological lights back on. Nothing has changed on that front. Nothing.
3 - Chemo is poison. Bavi doesn't work well in a poisonous environment apparently, despite the fantastically weird super efficacious Doxi control arm. So are the vagaries of biotech.
4 - BMS, Merck, Roche, and AZN have invested BILLIONS in the anti-PD1, anti-PDL1 mabs. Only BMS and Merck are raking right now because they were first in line. But the others aren't giving up. Why?
5 - Well, how 'bout combo therapy. It is a phenomenon well-known to the alternative/complementary medical field for decades. In fact, the whole Wall Street biotech immunotherapy racket is a rip-off of what natural holistic doctors have been saying for years.
6 - You don't treat breast cancer with just DIM (diindolylmethane, an anti-estrogen supplement); you add beta-carotene from natural sources (usually 8-10 blended organic carrot juices per day, plus duneliella algae food carotene - often to the tune of 200,000 IU daily), plus massive doses of Vitamin C, plus a no-sugar diet, plus alpha-lipoic acid, plus selenium, plus extra zinc to improve the zinc/copper ratio, plus Turmeric, plus Holy Basil.....etc.
Well, you get the idea. COMBO therapy. Plus, if someone has sizable, advanced breast cancer, it's probably a good idea to cut out as much out as possible. The tumor burden changes bio-electromagnetics throughout the body, thereby stressing it greatly; this is also why Bavi can't kill it.
But chemo and radiation stress the body even more, to the point that most cancer patients in this country die from chemotherapy. The researchers know it. The doctors know it. The nurses know it.
The only one who doesn't know it is the patient. They're just the wallet paying for it all despite ever more deaths from cancer over the past 50 years (cancer is soon to pass heart disease as our nation's #1 killer).
7. So why hold on to your shares. Well, Warren Buffet always says, "Buy and hold...forever." Yeah, I know, it already feels like forever, and that's disappointing for us long-suffering longs, but "c'est la vie."
8. I like the post on Avid being PPHM's lifeboat, otherwise Tustin would be packing boxes. True enough. Well, doesn't the BOD get any credit for thinking Avid through and pursuing it. NO small biotech out there has what PPHM has. Not one. Think about that.
9. I'm still adding when I scrounge up dry powder. That's my choice. You may not agree. Fine. I don't care.
10. My view is that someone will buy the PS platform sooner or later. For the grumpy bears, I know that is little consolation. But in my view, it's only a matter of time. The combos will demonstrate Bavi's critical role, and then it's just formalities from there.
Best regards always,
Joe "Six-Pack" Sulaco
