rGBM shows an efficacy signal in overall survival and how the tumor progresses along spider plots and along waterfall distribution plotting greatest reduction in tumor size as contrasted to standard of care....Avastin.
Ovarian cancer shows two signals with VB-111 in concert with platinum... one survival--although the trial is very small and the low-dose treatment arm only had 4 patients. Then again the biomarker response of CA-125 seems pretty consistent in terms of reduction. Thyroid shows again response.
Thyroid shows response in PFS and possibly overall survival ect... with VB-111 by itself.
The trials by definition are flawed, but only in the sense of a tiny micro cap trying to achieve an efficacy signal. Three distinct cancers, in different combinations... with avastin, with chemo, and by itself ...all showing an efficacy signal.
The other thing that caught my eye in the animal--preclinical evidence of tumor shrinkage and stabilization of tumor growth in different tumor types... lung, GBM and others.
While every biotech and their nephews all work in the same area.... checkpoint inhibitors and in CAR-T, crowding up the space, VBLT is working in a completely different manner. No, VB-111 is not curing cancer, but it may be extending life. The other piece of evidence thats encouraging is the immune infiltrates shown at ASCO in ovarian tumor patients. This fits in with the immune mechanism of action and the feverish response that the biotech shorts scoffed at.
Recent VBLT News
- Form S-1 - General form for registration of securities under the Securities Act of 1933 • Edgar (US Regulatory) • 06/20/2024 09:01:20 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/10/2024 09:18:35 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/10/2024 09:17:04 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/10/2024 09:12:59 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/10/2024 09:07:57 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/10/2024 09:06:57 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/10/2024 09:04:42 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/06/2024 08:30:44 PM
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- Form 8-K - Current report • Edgar (US Regulatory) • 04/12/2024 12:44:49 PM
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- Form 8-K - Current report • Edgar (US Regulatory) • 04/09/2024 09:20:13 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 04/08/2024 04:15:14 PM
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- Form 8-K - Current report • Edgar (US Regulatory) • 03/25/2024 01:00:14 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/22/2024 01:15:22 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 02/16/2024 02:00:13 PM
- Form PRE 14A - Other preliminary proxy statements • Edgar (US Regulatory) • 02/05/2024 10:00:08 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/02/2024 09:05:36 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/26/2024 04:05:45 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/26/2024 04:05:20 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/26/2024 04:04:43 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/26/2024 04:04:24 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/26/2024 04:02:17 PM
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