Molecular Pharmacology Ltd (MLPH)

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Molecular Pharmacology to Acquire Topical Cox-2 Inhibitor Candidate as Part of Australian Transaction
May 3, 2006 - 9:36 AM EDT

LOS ANGELES, May 3, 2006 (PRIMEZONE) -- Molecular Pharmacology (USA) Limited (OTCBB:MLPH) announced today the discovery of a new topically applied COX-2 inhibitor drug candidate MPL-356, following results by MDS Pharma Services (MDS), one of the world's leading independent pharmacology testing laboratories. The results were from a development program commenced by Molecular Pharmacology Limited Australia (MPLA), which is in the process of being acquired by MPL-USA and returned encouraging results in COX-2 inhibition studies. The study and follow-up replication and dose response study, conducted by MDS's Taiwan laboratory, evaluated MPL-356 in the inhibition of human Cyclooxygenase COX-2 in vitro with results reporting inhibition of up to 90% of the key pro-inflammatory enzyme.

The COX-2 enzyme is the primary biological target in the treatment of osteo-arthritis, however, safety concerns regarding potential side effects of some oral COX-2 inhibitors have resulted in global product withdrawals. Topical COX-2 inhibitors have the potential to avoid such systemic side effects while retaining the anti-arthritic benefits.

CS-356 was discovered by Cambridge Scientific Pty Ltd., and, under the terms and conditions of the exclusive world-wide license between Cambridge and MPLA, MPL-USA is automatically granted the world-wide exclusive rights to commercialize the topical analgesic and anti-inflammatory properties of MPL-356 in humans.

About Molecular Pharmacology (USA) Limited

Molecular Pharmacology (USA) Limited (OTCBB:MPLH) is a public biotechnology company dedicated to the discovery and development of analgesic and anti-inflammatory products based on the proprietary MPL-TL compound. MPL USA holds the exclusive worldwide rights to develop new and fast-acting analgesic and anti-inflammatory products based on MPL-TL. For more information on MPL USA, please visit www.mpl-usa.com.


CONTACT: Molecular Pharmacology (USA) Limited
Ian Downs
[phone]


Source: PrimeZone (May 3, 2006 - 9:36 AM EDT)

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