Vascular Biogenics Ltd (VBLT)

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Title: Clinical Data Presented at ASCO Demonstrate Significant Overall Survival Benefit in rGBM Patients Receiving VB-111 Compared with Historical Avastin® Meta-analysis Data

Date(s): 3-Jun-2016

VBL's Phase 2 study in recurrent glioblastoma (rGBM) met the primary endpoint of statistically-significant increase in median overall survival, with 59 weeks in patients treated with continuous exposure of VB-111, compared to 32 weeks in patients with limited VB-111 exposure (p=0.048).
Median overall survival for patients on continuous exposure of VB-111 was 59 weeks, compared with 32 weeks in historical pooled Avastin trials (p= 0.0295).
12-Month overall survival was 57% in patients on continuous exposure of VB-111, compared with 24% in historical pooled Avastin trials (p=0.03).
TEL AVIV, Israel, June 03, 2016 (GLOBE NEWSWIRE) -- VBL Therapeutics (Nasdaq:VBLT), today announced the presentation of new data comparing clinical outcomes with VB-111 with pooled data from 8 studies that investigated Avastin® (bevacizumab) in recurrent glioblastoma (rGBM). The data are presented at the 2016 American Society of Clinical Oncology (ASCO) annual meeting, taking place in Chicago.

A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/a06ea8e4-2295-4ae2-ae38-9f08925037f3

The study, "VB-111, An Anti-Cancer Gene Therapy in Combination with Avastin Significantly Improves Overall Survival Compared to Avastin Monotherapy in Patients with rGBM: A Phase 2 Historically Controlled Trial," was based on a literature search of studies investigating Avastin in GBM patients, published during the period January 2005 to November 2015. Out of 662 abstracts and 53 full text articles assessed for eligibility, the independent academic investigators identified 8 studies for inclusion in a meta-analysis, outcomes were then compared with the VB-111 Phase 2 data in rGBM. Survival data from these studies was extracted based on tables giving individual patient data or directly from Kaplan-Meier curves using software which converted curves into numerical data.

In the Phase 2 VB-111 trial, the median overall survival of patients who received continuous exposure of VB-111 in combination with Avastin was 59 weeks. This is compared to 32 weeks in the pooled data from the 8 studies in the meta-analysis (p= 0.0295; Hazard Ratio 0.62, 95% CI: 0.40-0.96). Median survival ranged from 26.0 weeks to 45.7 weeks in the meta-analysis. Overall survival at 12 months for patients on continuous exposure of VB-111 was 57%, compared with 24% overall survival (range 16% - 38%) for the pooled Avastin® treated rGBM data (p= 0.03).

"This meta-analysis provides a large dataset from diverse sources, which is pooled together to provide a reliable historical control group; superiority of VB-111 continuous exposure over this control group supports our belief that VB-111 used in combination with Avastin can potentially prolong survival in rGBM compared with Avastin alone," said Yael Cohen, MD, Vice President of Clinical Development at VBL Therapeutics. "The ongoing Phase 3 randomized controlled GLOBE study of VB-111 in combination with Avastin, which is being conducted in the U.S., Canada and Israel, is proceeding on track and our goal is to conduct an event-driven interim analysis according to the study protocol. While the timing of the interim analysis depends on enrollment and VB-111 activity, we expect to conduct it in the first half of 2017."

The Phase 2 trial was a multi-center study designed to determine the safety, tolerability and efficacy of VB-111 in patients with rGBM. A total of 46 patients were enrolled. In the first stage of the study, patients were treated with VB-111 alone. Upon disease progression, patients entered the second stage of the study, in which they received either Avastin alone as standard of care (limited exposure cohort) or VB-111 in combination with Avastin (continuous exposure cohort). The primary endpoint was overall survival (OS). VBL previously announced data from this study at the 2015 ASCO meeting and at the European Cancer Congress 2015.

VBL's ongoing pivotal Phase 3 GLOBE study in rGBM is comparing VB-111 in combination with Avastin to Avastin alone and is recruiting about 252 patients in the US, Canada and Israel. The study is proceeding under a Special Protocol Assessment (SPA) granted by the FDA, with full endorsement by the Canadian Brain Tumor Consortium (CBTC). VB-111 has received orphan drug designation in the United States and Europe and was granted Fast Track designation by the FDA for prolongation of survival in patients with glioblastoma that has recurred following treatment with standard chemotherapy and radiation.