You got it, oxidative stress and so on...will indicate if the drug works or not but for me it sounds like Shire want to go forward after evaluate their options. The drug is save.
Things that are equal to the same thing are also equal to one another (Transitive property of equality). If equals are added to equals, then the wholes are equal. If equals are subtracted from equals, then the remainders are equal. Things that coincide wi