Saturday, April 23, 2016 8:41:04 PM
A single lesion (0.5-2.0 cm) in each patient was treated with IL-2 (3 mIU) IT TIW x 2 weeks, then BIW x 6 weeks, with escalating doses of Ipi IT weekly x 8 wks. A minimum of 3 patients were enrolled at each dose level. Endpoints included safety, tumor responses, and changes in systemic T cells. Results: 12 patients were treated at 3 Ipi dose levels (0.5, 1, 2 mg). Treatments were well tolerated. The only grade 3 toxicity observed was injection/tumor site ulceration/necrosis, not a DLT per protocol. Other toxicities were grade 1 in nature. An abscopal effect (response in at least 1 non-injected lesion) was seen in 9/12 patients (75%). 10 patients were evaluable for response by immune-related response criteria: 4 PR (40%) and 6 PD. 1 PD was later found to be a CR by resection. The 2 nonevaluable patients had regression of multiple skin lesions.
Recent ONCSQ News
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 02/13/2024 07:30:19 PM
NanoViricides Reports that the Phase I NV-387 Clinical Trial is Completed Successfully and Data Lock is Expected Soon • NNVC • May 2, 2024 10:07 AM
ILUS Files Form 10-K and Provides Shareholder Update • ILUS • May 2, 2024 8:52 AM
Avant Technologies Names New CEO Following Acquisition of Healthcare Technology and Data Integration Firm • AVAI • May 2, 2024 8:00 AM
Bantec Engaged in a Letter of Intent to Acquire a Small New Jersey Based Manufacturing Company • BANT • May 1, 2024 10:00 AM
Cannabix Technologies to Deliver Breath Logix Alcohol Screening Device to Australia • BLO • Apr 30, 2024 8:53 AM
Hydromer, Inc. Reports Preliminary Unaudited Financial Results for First Quarter 2024 • HYDI • Apr 29, 2024 9:10 AM