A very good post from Yahoo Board.
The True Potential of Pro-140-Functional Cure 1/2
In the early days of Hep C (HCV) treatment (Tx), we started with interferon, achieving an 8% Sustained Virological Response (SVR), (SVR=virally negative 6 months after end of treatment) then added Ribaviran, boosted it to low 20's. In 2002 we pegylated the interferon and discovered we could achieve at 40+% SVR. Vertex entered the market, studying Telaprivir, adjunct therepy to the P-INF+RBV backbone. Achieving a 70+% SVR. HCV behaved similarly to HIV in that it hid out in extra vascular compartments much like HIV does. Although HIV is far more insidious. Abbvie and Gilead began studying their respective cocktails, both achieving nearly a 100% SVR in patients that take their medication. So far HAART has done a great job of ridding the body of circulating virus, but nothing to mop up dormant virus. It was once thought that if a patient was on HAART long enough they would be able to be taken off treatment. That's proven not to be the case. In 2007/8 oral entry inhibitors Mariviroc and Vicroviroc were being studied. While Mariviroc was granted marketing approval, Vicroviroc failed to meet its primary endpoints and the program was halted. Mariviroc is basically a DOG that no one uses. It interferes with the other important inflamatory response fuctions CCR5 that PRO140 Does not. I believe very strongly that PRO140, once fully studied and its capabilities born out, will surpass any candidate currently on the market or in development. This Molecule is unique in it mode of action. HIV is not a 1 Billion dollar market, Its a 100 Billion market, once the glabal impact, Prevention (Prep), & Post Exp (PEP) markets are fully exploited. Finally, the ability of PRO140 to be delivered SC with potential of even greater interval dosing (ie once a month, once a quarter? PRO140 could very possibly own this entire market in a very short time. Lets Make sure this Company has all the Capital it needs to succeed. We R Part of something special
