Wisdom is a good thing. Rashness is not. Incontrovertible. As for how it applies to HB, I can only recall www.ft.com/intl/cms/s/2/c5d45314-3db3-11e3-9928-00144feab7de.html#axzz3UfK7qyTa this gem : Investigators had informed the company about the frequency of CV events seen in EPIC, but “Ariad was not listening,” the second source said. Just sayin