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Sunday, April 03, 2016 9:11:30 PM
-ALD1613 Administration Reduces Plasma Corticosterone in Multiple Preclinical Models-
http://finance.yahoo.com/news/alder-presents-preclinical-data-ald1613-171500565.html
Key Points:
In vitro, ALD1613 inhibits ACTH-induced cortisol secretion in a mouse adrenal cell line.
ALD1613 administration in rats with artificially elevated ACTH and corticosterone levels resulted in a rapid and durable reduction of plasma corticosterone levels.
In non-human primates, ALD1613 demonstrated stable and durable reductions in plasma cortisol levels by >50%.
Randall C. Schatzman, Ph.D., President and Chief Executive Officer of Alder, said, “Existing therapeutic options for patients with congenital adrenal hyperplasia and Cushing's disease comprise treatments that provide limited disease control and involve significant side effects. We believe these limitations indicate a clear need for new therapies such as ALD1613, which targets ACTH to diminish the overproduction of cortisol. The data presented today demonstrate the capacity of ALD1613 to reduce corticosteroid levels in preclinical settings. We intend to use these studies as part of an IND filing that we plan to submit to the FDA in the second half of 2016.”
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