Vivos Inc (RDGL)

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How long is the procedure and any follow up injections?

Answer: Just a few minutes, depending on tumor type. The tumor is injected with a single or multiple injection squirts, depending on various factors. We presume that no follow-up injections will be necessary, although a second treatment could be given if any parts of the tumor survive. Some tumors will need to be reached intraoperatively, meaning that the patient will be anesthetized and opened surgically to access the tumor.

Radiogel comprises a two-part sterile product that is
mixed in precise amounts immediately prior to
injection: Part A is a pre-calibrated, sterile solution of highly insoluble 90Y-phosphate microspheres in a phosphate-buffered saline. Part B is a
sterile isotonic, water-based polymer solution which will act as a microsphere carrier during injection and as a container material after gelation. Parts A and B are cooled in ice, and then combined for injection. The injected solution perfuses tumor tissue and displaces extracellular fluids. As the polymer warms to body temperature, the water-based carrier solution undergoes a phase transition to a solid gel, and the polymers form cross-links that entrap the 90Y microspheres
and prevent redistribution throughout the body. The insoluble phosphate crystal
also prevents dissolution and migration of free 90Y.

The part B is essentially water.