Innovation Pharmaceuticals Inc (IPIX)

[biodoc]

Yes, very much in line with CallMeCrazy. Once approved, most medicines can be prescribed at a physician's discretion. If Prurisol proves beneficial and is approved for mild/moderate plaque psoriasis, then I could easily see a physician prescribing it for a case of severe psoriasis to see (1) if it helps (2) if the side effects are easily managed and (3) to avoid the very, very costly biologics.

Biologics, including Cosentyx, Humira, Enbrel, Remicade, Stelara cost around 20k per year, sometimes lose effectiveness and are rarely(?) prescribed for mild disease.

Orally available Otezla, btw, had PASI-75 response rates of 40% at 16 weeks (12% placebo response rate) and 53% at 32 weeks for moderate/severe plaque psoriasis. PASI-75 correlates to an IGA score of 0/1 which is the clear or almost clear target we are hoping for with Prurisol for treatment of less severe mild/moderate disease.

Note Leo's mention of the short duration of the Prurisol trial- treatment duration is only 12 weeks.

It's a very ambitious trial with low risk and huge upside.