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Re: Ernesto post# 143138

Thursday, 03/24/2016 9:59:32 PM

Thursday, March 24, 2016 9:59:32 PM

Post# of 403742
I really appreciate your provocative and reasoned response. I had no idea they were pursuing such an odd goal- looking at specific lesions as opposed to a global assessment.

They show mice with striking global responses. what evr could be the logic of such a narrow focus? I cannot grasp it at all, and I failed to appreciate it despite reading about the trial earlier today- I did not read closely enough at all- thanks to Leo, and to your note, about the aims of the the trial. Pretty strange I think.

All of their competition( esp the monoclonals)report on the basis of overall improvement such as the PASI 75 measure Leo referred to in a recent PR, referencing Otzela and its success- albeit limited success, about a 30% response rate for moderate plaque psoriasis

I will re-read the paid puff piece and connect the dots if possible. The trial seems more mysterious to me. So few patients, for a short period of time, looking at single lesions? Yeesh.

If successful looking toward much bigger trial with wider response end points of course, with this trial as proof of concept only.

Possibly pivotal moment for CTIX if success as it will provide a chance to partner and to fund other trials(K).

Hard to fathom. We shall see.