Innovation Pharmaceuticals Inc (IPIX)

[KMBJN]

More on various ovarian cancer treatments:

National Academy of Science came out with a report recently

http://nationalacademies.org/hmd/Reports/2016/State-of-Ovarian-Cancer.aspx

One of the chapters discusses targeted therapies:

"The molecular analysis of HGSC by TCGA Research Network revealed the presence of “TP53 mutations in almost all tumors (96 percent) [and] low prevalence but statistically recurrent somatic mutations in nine further genes” (Cancer Genome Atlas Research Network, 2011, p. 609). Because p53 is the nexus of various tumor suppressive pathways, it would probably be of benefit to reactivate or restore p53 function in order to revert or rescue cells from resistance to standard chemotherapeutic treatments (Carrillo et al., 2015; Mohell et al., 2015). A clinical trial is currently under way to investigate the use of a p53-reactivating compound APR-246 in ovarian cancer (Aprea AB, 2014)."

Soon we'll be able to add Kevetrin to the short list of p53-activating compounds being investigated for ovarian cancer.

Maybe they'll have multiple arms in the PII: K monotherapy at a high dose [q. 4 days x 3 wks + 1wk off], K low dose [same dosing frequency] + SOC, and K high dose [same dosing regimen] + SOC. Who knows.


Ran across this piece of news from CLSN: investigating an immune activating cytokine IL-12 local gene therapy "GEN-1," to be used in combo with standard chemo (Doxil) and a VEGF inhibitor (Avastin) in recurrent ovarian cancer:

http://finance.yahoo.com/news/celsion-announces-presentation-preclinical-data-203500188.html


I think combination therapies may be the way to go. Combine standard chemo to kill the cancer, p53-activating drug like K to enhance tumor killing, VEGF inhibitor to starve the tumor's blood supply, and IL-12 and/or other immune stimulating therapies (anti-PD1 or similar checkpoint inhibitors, CAR-T, etc...) to ramp up the immune system to kill the cancer. Hit the enemy from every angle!

Inovio is studying DNA based cancer vaccines using the same IL-12 immune stimulator, but ovarian cancer is one cancer for which they are not developing a vaccine at present.


More on combining chemo with immunotherapies:

http://www.barrons.com/articles/cancer-therapy-may-see-major-shift-1458071085