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Re: KMBJN post# 141668

Thursday, 03/10/2016 8:05:53 AM

Thursday, March 10, 2016 8:05:53 AM

Post# of 403248
helpful links. There are the straightforward details of one current competitor- 6 hour dosing 4x week 4 days a week. The patients will certainly wish they had a pump option , even if they are binge watching House of Cards. Where apr-246 has an edge is that the drug has already been given in different doses as part of the p1b, whereas K dosing prob not dialed in- that would be my guess only, and those trial pharmacologists may know better.

None of this matters except efficacy of course. Prob both drugs will be available here in Boston soon, but as noted , for different groups of patients- relapsed, but platinum sensitive for apr246 /carboplatin versus platinum resistant for K/docetaxel
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