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Monday, February 22, 2016 10:41:52 AM
One could question several other things:
(1) why didn't everyone have an increase in p21 expression?
(2) why were some of the assay results uninterpretable (8 subjects)?
In any event, it's nice to see that on average, those with low dose K had a small p21 increase, and those with higher doses had a larger increase. As we had discussed before when statements were made about kevetrin having a dose-response for p21, it will be nice to see the raw data to see how reproducible the result is across subjects, and even within the same subject.
Then there's the whole question of does p21 increase correspond with clinical outcomes (as it appeared to do in animal model)? We have heard relatively nothing about clinical efficacy, except one of the last PRs says "suggestive evidence of the potential clinical benefit of" K.
Overall, this is a nice result. Maybe we'll see more details in a publication in preparation. We'll have to wait for Phase II to (hopefully) see efficacy.
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