Saturday, February 20, 2016 4:38:08 PM
For those that like to keep track.... BOD changes from 2014 to 2016 and still waiting on the full list of speakers and all topics.
Board of Directors, ICDS - Feb 2014
Patrizia Agostinis; Raymond Birge; Christoph Borner; Marianne Cronje; Katharina D’Herde; Devrim Gozuacik; Roya Khosravi-Far; Simone Fulda; Nader Maghsoudi; Seamus Martin; Soraya Smaili; Eileen White; Junying Yuan; Zahra Zakeri
Changes as of Feb 20, 2016
Outgoing: Seamus Martin
New Additions: Eli Arama, Francesco Cecconi, Tom Cotter
ICDS Advisory Board - Feb 20, 2016
Douglas Green; Marie-Lise Gougeon; Michael Hengartner; H. Robert Horvitz; Marja Jäättelä; Adi Kimchi;Sharad Kumar; Sergio Lavandero; Richard A. Lockshin; Carlos Martínez; Shigekazu Nagata; Don Nicholson; Mauro Piacentini; Jun-Ying Yuan; Boris Zhivotovsky
http://www.celldeath-apoptosis.org/oursoci/board-of-directors.html
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CHAIRS
Eli Arama (Israel)
Ray Birge, ( U.S.A):
Dhyan Chandra, (USA)
Jerry Chipuk, (U.S.A)
Marianne Cronje (South Africa)
Devrim Gozuacik, (Turkey):
Annie Joubert, (South Africa):
Samuel Katz (U.S.A)
Zahra Zakeri, (USA)
PARTIAL LIST OF SPEAKERS (Alphabetical order)
Eli Arama (Israel): Move or Die: Linking caspases and cell migration and invasion in Drosophila
Frank-Dietmar Böhmer (Germany ) : Redox regulation of FLT3ITD signaling in cells of Acute Myeloid Leukemia
Rolf Brekken, (USA): blockade of phosphatidylserine and immune activation in cancer’
Marcos A. Carpio: (U.S.A): TBA
Tom Cotter ( Ireland): TBA
Marc Diederich, (Luxemberg ): Cardenolides trigger mitophagy, apoptosis or necroptsis in human neuroblastoma
Zvi Fishelson, (Israel): Activators and inhibitors of programmed necrotic cell death induced by the complement C5b-9 complex
Simone Fulda, (Germany): Novel opportunities for exploiting programmed cell death pathways for cancer therapy
Adrienne Gorman, (Ireland): TBA
Atan Gross (Israel): Importance of mitochondria metabolism for regulating the DNA damage response in hematopoietic stem cells
William Kaiser, (U.S.A): Death’s trap door: necroptosis in host defense
Sarit Larisch, (Israel): ARTS initiates apoptosis by regulating XIAP and Bcl-2 family members
Seamus Martin (Ireland): Cell Death: An Inflammatory Perspective'
Triona Ni Chonghaile, (Ireland):Determining Mitochondria's Distance to Death's Door
Erik Norberg, (Sweden): Profiling and Targeting of Tumor Metabolism
Helin Norberg, (Sweden): CMA, Metabolic catastrophe and Cell Death
Benedicte Py. (France):Regulation of the NLRP3 inflammasome by post-translational modifications
Hermann Steller (USA): Regulation of apoptosis in development, stem cells and cancer
Alex Tonks (UK): The role of reactive oxygen species in acute myeloid leukaemia; cell death, proliferation and metabolism
Boris Zhivotovsky, (Sweden): miRNAs' role in sensitivity of lung adenocarcinoma to treatment
http://www.celldeath-apoptosis.org/extensions/templates/beez5/next-meeting-html/typography-beez-5/speakers-topics.html
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Tom Cotter:
Research Interests
The main research focus in the Cotter Laboratory is in understanding the role of cell signalling pathways, in particular those that are redox regulated and active, in tumour cell survival and in degenerative conditions of the retina. The role of reactive oxygen species such as hydrogen peroxide has undergone a renaissance in the last decade with this molecule shown to be acting as both a driver of cell death (at high concentrations) but also more significantly as a specific activator of cell survival pathways at lower concentrations.
In the case of several tumours both leukaemia and colon we see an increase in ROS production on oncogene activation. From multiphoton microscopy this increase appears to be localised to the ER and is produced by activation of one member of the NADPH Oxidase (Nox) family of enzymes. This in turn activates the Akt/PI3k pathway by the inhibition of one of several negatively regulating phosphatases. The result is a stronger tumour cell survival signal which aids tumour development and hinder chemotherapeutic treatments.In the retina our focus is also on the signalling role of ROS specifically how it contributes to post-mitotic cells cell survival either following short term stress or via growth factor signalling. This is particularly important as we strive to understand what occurs at the biochemical level during degenerative retinal diseases. We are also exploring new molecular therapies and the role played by cells such as glial cells which are not directly involved in the visual process itself, but which are none the less vital for the process.
http://publish.ucc.ie/researchprofiles/D003/tcotter
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Lets go Tom, Eye see you just may have been paying attention to PS Targeting and all those negative charges at the surfae. Speak... everyone speak up : ) To Ireland we go!
https://vimeo.com/62115945
"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!
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