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Re: Echo20 post# 139669

Thursday, 02/11/2016 11:14:06 AM

Thursday, February 11, 2016 11:14:06 AM

Post# of 403159
As prev noted on this board: just read about the lifespans of your red and white blood cells. Neutropenia esp has proven to be a sticking point for many many drugs chemo and otherwise, incl the MDM2 drugs.

Giving K more frequently MAY have toxicity we do not know about yet- it has never been given 3x week, right? Your bone marrow has plenty of time to recover if it takes a hit with a short half life drug given once a week. Maybe 3x week no impact.

But maybe a real impact on cells whose life spans are VERY short/produced in massive numbers every hour/day. Even if DFCI has shown NO decrease in neutrophils with highest doses so far, it still does not mean K will have no adverse effects as dosing changes
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