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Re: tradero post# 252616

Tuesday, 02/09/2016 6:01:16 PM

Tuesday, February 09, 2016 6:01:16 PM

Post# of 345980

I think there are good reasons to be optmistic.


Believe it or not, I do not find your core numbers for expected event that bad. Methodology is sound (unless I missed something). Some minor issues at the bottom of this post.

On major issues to bring up:

. The reporting of "we reached 154 (or whatever) events" is generally delayed by a month or two. This is because of the process.

. I suspect the placebo arm will come in with longer OS than your sample trial. Happens very often.

Quibbles:

. It would be a hell of a lot easier to read your key chart (that one with the yellow bar across the 12m group) if the 4th column was % survival as directly read off the prototype trial chart. I.E., 12 months = 39%

. I think you are sliding a month. I admit I always get sloppy/confused myself on this issue.

. I tend to see a few small errors that might be rounding. Would be easier to verify numbers if you addressed my first quibble. smile

Regardless, thanks for clarifying your post. I still certainly disagree about what "33%" means though.

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